Effects of naloxone on pethidine-induced neonatal depression. Part II--Intramuscular naloxone.
Open Access
- 23 July 1977
- Vol. 2 (6081) , 229-231
- https://doi.org/10.1136/bmj.2.6081.229
Abstract
Thirty full-term infants whose mothers had had pethidine during labour were given either naloxone 200 microgram or normal saline intramuscularly. The drugs were chosen blindly and administered within one minute of birth. Naloxone produced a significant reduction in mean alveolar carbon dioxide tension and an increase in carbon dioxide excretion and mean alveolar ventilation at all times up to 48 hours after birth. The mean rate of habituation to a repeated auditory stimulus, the mean sucking frequency, the sucking pressure, and the mean consumption of milk were all significantly higher in the naloxone-treated group than in the placebo-treated group up to 48 hours after birth. Intramuscular naxolone therefore seemed to reverse the undesirable effects of pethidine.Keywords
This publication has 5 references indexed in Scilit:
- Degree and Duration of Reversal by Naloxone of Effects of Morphine in Conscious SubjectsBMJ, 1974
- Obstetric Meperidine Usage and Assessment of Neonatal StatusAnesthesiology, 1974
- The relation between laboratory measures of sucking, food intake, and perinatal factors during the newborn period.1969
- The Effect of Pethidine on the Postnatal Adjustment of Respiration and Acid Base BalancePublished by Wiley ,1968
- Newborn Sucking Behavior Affected by Obstetric SedationPediatrics, 1966