DETECTION AND SEPARATION OF 2 SERUM FACTORS RESPONSIBLE FOR DEPRESSION OF LYMPHOCYTE ACTIVITY IN PREGNANCY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 32  (2) , 318-323
Abstract
Rosette inhibition demonstrated a depression of lymphocyte activity in pregnant mice as early as 6 h after fertilization which persisted until just before delivery. This depression of lymphocyte activity was induced by 2 serum factors, the relative contributions of which vary with the time of gestation. The 1st, a high MW early pregnancy factor, appeared within hours of fertilizaton and then slowly declined in activity as gestation proceeded. The 22nd, a lower MW substance which cross-reacted with antiserum to human chorionic gonadotrophin, appeared after the formation of the trophoblast at 4-5 days and persisted until parturition.