Differential efficacy of mebendazole and albendazole againstNecator americanus but not forTrichuris trichiura infestations

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Abstract
The effect of single oral doses of albendazole 600 mg and mebendazole 1 g given to 56 and 60 men, respectively, withT. trichiura and/orN. americanus infestation has been studied. Both albendazole and mebendazole cured more than 90% ofT. trichiura infestations, but only albendazole (95%) and not mebendazole (21%) had a high cure rate forN. americanus infestations. Thus, albendazole is the preferred benzimidazole derivate for the mass treatment of subjects withT. trichiura and/orN. americanus infestations.