Antiproliferative effect of interferons on human prostate carcinoma cell lines
- 1 March 1989
- journal article
- research article
- Published by Springer Nature in Urological Research
- Vol. 17 (2) , 111-115
- https://doi.org/10.1007/bf00262031
Abstract
Summary The effect of purified human fibroblast beta-interferon (B-IFN) and recombinant alpha-2b-interferon (A-IFN) on cell proliferation was investigated in two human prostate carcinoma cell lines, named PC-3 and DU-145. Both cell lines respond to the antiproliferative action of interferon, B-IFN being more effective than A-IFN. PC-3 is more sensitive than DU-145 cell line, showing 95% inhibition of cell proliferation at the highest concentration of B-IFN. As interferons, besides reducing cell growth, are able to modify steroid receptor content in different hormonesensitive human tumours, our results may be of some relevance as these drugs might be used to regulate both cell proliferation and hormone-sensitivity in prostate cancer.Keywords
This publication has 16 references indexed in Scilit:
- In Vitro effects of β-interferon on steroid receptors and prostaglandin output in human endometrial adenocarcinomaJournal of Steroid Biochemistry, 1988
- Effects of human lymphoblastoid interferon on cultured breast cancer cellsInternational Journal of Cancer, 1981
- SENSITIVITY OF HUMAN OVARIAN CARCINOMA CELLS TO INTERFERON AND OTHER ANTITUMOR AGENTS AS ASSESSED BY AN IN VITRO SEMI‐SOLID AGAR TECHNIQUE*Annals of the New York Academy of Sciences, 1980
- Role of G0-G1 arrest in the inhibition of tumor cell growth by interferon.Proceedings of the National Academy of Sciences, 1980
- Effect of interferon on concentrations of cyclic nucleotides in cultured cells.Proceedings of the National Academy of Sciences, 1979
- Interferon effects on the growth and division of human fibroblastsExperimental Cell Research, 1979
- Isolation of a human prostate carcinoma cell line (DU 145)International Journal of Cancer, 1978
- Sensitivity of various human lymphoblastoid cells to the antiviral and anticellular activity of human leukocyte interferonArchiv für die gesamte Virusforschung, 1977
- Is Interferon Tissue Specific? -- Effect of Human Leukocyte and Fibroblast Interferons on the Growth of Lymphoblastoid and Osteosarcoma Cell LinesJournal of General Virology, 1977
- Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue cultureInternational Journal of Cancer, 1977