The antagonism of benzodiazepine withdrawal effects by the selective cholecystokininB receptor antagonist CI-988

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Abstract
The ability of a selective cholecystokininB (CCKB) receptor antagonist, CI-988, to block benzodiazepine withdrawal effects was examined in mice. The discontinuation of twice daily administration of diazepam (1 mg kg−1, i.p.) induced withdrawal anxiogenesis and a proconvulsant effect. In contrast, no such effects were seen following withdrawal from similar administration of CI-988. However, CI-988 dose-dependently (0.001–1.0 mg kg−1, s.c.) antagonized both the anxiogenesis and the proconvulsant effect following diazepam-withdrawal.