IMMUNOLOGICAL MECHANISMS IN PATHOGENESIS OF VIRUS-INDUCED MURINE LEUKEMIA .3. TARGET-CELL SPECIFICITY OF AUTOREACTIVE THYMOCYTES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 117  (1) , 11-15
Abstract
Thymocytes from preleukemic mice persistently infected with Moloney murine leukemia virus (MuLV-M-carriers) were vigorously autoaggressive toward normal syngeneic [embryo] target cells; they exhibited a graded response to allogeneic cells, but they spared xenogeneic cells [human embryonic lung fibroblast WI38 cells] or syngeneic cells infected with MuLV-M or MuLV-G (Gross). Syngeneic target cells infected with nononcogenic lymphocytic choriomeningitis virus (LCMV), or transformed by the chemical carcinogen 3-methylcholanthrene were not similarly spared. This phenomenon, apparently induced by MuLV-M, is not associated with all persistent virus carrier states. Thymocytes from mice persistently infected with LCMV or with the lactic dehydrogenase virus (LDHV) failed to demonstrate an autoaggressive behavior. That transplantable lymphoma cells (derived from MuLV-M-carriers) were autoreactive in a pattern similar to thymocytes from preleukemic mice, suggests a unique role for MuLV in the events leading from altered recognition of self to lymphoma.

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