Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in the serum of patients with thyroid‐associated ophthalmopathy
- 9 May 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 232 (1) , 135-139
- https://doi.org/10.1016/0014-5793(88)80402-2
Abstract
A 64 kDa protein has been identified in the membrane fraction of human eye muscle, orbital connective tissue and thyroid, by testing sera of patients with thyroid‐associated ophthalmopathy in SDS‐polyacrylamide gel electrophoresis and Western blotting. Antibodies to this membrane antigen seem characteristic of the early stage of ophthalmopathy. In the thyroid this newly recognized protein seems different from previously known membrane antigens. A thyroid antibody reactive with a 64 kDa membrane antigen in eye muscle could explain the very frequent association of ophthalmopathy with autoimmune thyroid disease.Keywords
This publication has 6 references indexed in Scilit:
- Antibodies to Porcine Eye Muscle in Patients with Graves’ Ophthalmopathy: Identification of Serum Immunoglobulins Directed Against Unique Determinants by Immunoblotting and Enzyme-Linked Immunosorbent Assay*Journal of Clinical Endocrinology & Metabolism, 1987
- The subunit structure of the thyrotropin receptorBiochemical Society Transactions, 1987
- Immunochemical Characterization of Anti-Islet Cell Surface Monoclonal Antibody From Nonobese Diabetic MiceDiabetes, 1986
- Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseasesFEBS Letters, 1985
- Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteinsNature, 1982
- Modification of the Classification of the Eye Changes of Graves' Disease: Recommendations of the Ad Hoc Committee of The American Thyroid AssociationJournal of Clinical Endocrinology & Metabolism, 1977