ABO blood group also influences the von Willebrand factor (VWF) antigen level in heterozygous carriers of VWF null alleles, type 2N mutation Arg854Gln, and the missense mutation Cys2362Phe
- 1 September 2002
- journal article
- Published by American Society of Hematology in Blood
- Vol. 100 (5) , 1927-1928
- https://doi.org/10.1182/blood-2002-04-1168
Abstract
The levels of von Willebrand factor (VWF) in plasma are influenced by several variables, such as age, blood group, pregnancy, hormones, and smoking. The VWF levels may vary greatly on repeated laboratory testing in the same subject.[1][1] About 60% of the variation in plasma VWF is caused by geneticKeywords
This publication has 10 references indexed in Scilit:
- A novel family with recessive von Willebrand disease due to compound heterozygosity for a splice site mutation and a missense mutation in the von Willebrand factor geneThrombosis Research, 2002
- The Half-life of Infused Factor VIII Is Shorter in Hemophiliac Patients with Blood Group 0 than in those with Blood Group AThrombosis and Haemostasis, 2000
- Characterization of the Genetic Defects in Recessive Type 1 and Type 3 von Willebrand Disease Patients of Italian OriginThrombosis and Haemostasis, 1998
- Von willebrand disease and quantitative variation in von willebrand factorJournal of Laboratory and Clinical Medicine, 1997
- Effects of the mutant von Willebrand factor gene in von Willebrand diseaseHuman Genetics, 1995
- Prevalence of von Willebrand disease in children: A multiethnic studyThe Journal of Pediatrics, 1993
- The bleeding time in normal subjects is mainly determined by platelet von Willebrand factor and is independent from blood groupThrombosis Research, 1992
- Heterogeneous phenotypes of platelet and plasma von Willebrand factor in obligatory heterozygotes for severe von Willebrand diseaseBlood, 1989
- The effect of ABO blood group on the diagnosis of von Willebrand diseaseBlood, 1987
- Epidemiological investigation of the prevalence of von Willebrand's diseaseBlood, 1987