Simple parameterization of non‐proteinogenic amino acids for QSAR of antibacterial peptides
- 20 June 2002
- journal article
- research article
- Published by Wiley in Journal of Peptide Science
- Vol. 8 (7) , 302-306
- https://doi.org/10.1002/psc.403
Abstract
The antibacterial activity of bovine lactoferricin‐(17–31)‐pentadecapeptide against Escherichia coli and Staphylococcus aureus is sensitive to substitution of the Trp residues, and synthetic peptides with phenylalanine and any of eight non‐proteinogenic aromatic amino acids greatly affected antibiotic activity. Using simple size‐related descriptors for the new amino acids it is possible to develop quantitative structure–activity relationships (QSARs) that can be used as tools in the search for more active peptides. Copyright © 2002 European Peptide Society and John Wiley & Sons, Ltd.Keywords
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