A Case of Cushing's Syndrome Treated with Testosterone Propionate1

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Abstract
The case is presented of a boy, age 17, showing typical signs of Cushing''s syndrome: osteoporosis of the spine and ribs, diabetic glucose tolerance curve, resistance to insulin, hypertension, decrease in libido, hirsutism, generalized muscular weakness, buffalo type of fat distribution and purple striae with normal genitalia. The urinary 17-ketosteroids were normal. The serum Na was markedly elevated. X-ray plates of the sella turcica and adrenal regions showed normal conditions. Under testosterone propionate treatment the boy showed marked gain in strength with a very pronounced increase in the excretion of creatine and a slight increase in creatinine excretion. The blood creatine was also increased. There was an increase in libido. There was no change in the osteoporosis, hypertension or Ca excretion.

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