Synergistic Activities of Macrolide Antibiotics against Pseudomonas aeruginosa , Burkholderia cepacia , Stenotrophomonas maltophilia , and Alcaligenes xylosoxidans Isolated from Patients with Cystic Fibrosis
Open Access
- 1 April 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (4) , 1105-1107
- https://doi.org/10.1128/aac.46.4.1105-1107.2002
Abstract
Azithromycin and clarithromycin were paired with other antibiotics to test synergistic activity against 300 multidrug-resistant pathogens isolated from cystic fibrosis (CF) patients. Clarithromycin-tobramycin was most active against Pseudomonas aeruginosa and inhibited 58% of strains. Azithromycin-trimethoprim-sulfamethoxazole, azithromycin-ceftazidime, and azithromycin-doxycycline or azithromycin-trimethoprim-sulfamethoxazole inhibited 40, 20, and 22% of Stenotrophomonas maltophilia, Burkholderia cepacia complex, and Achromobacter (Alcaligenes) xylosoxidans strains, respectively.Keywords
This publication has 26 references indexed in Scilit:
- Identification and Antimicrobial Susceptibility of Alcaligenes xylosoxidans Isolated from Patients with Cystic FibrosisJournal of Clinical Microbiology, 2001
- Anti-inflammatory activity of macrolides: a new therapeutic potential?Journal of Antimicrobial Chemotherapy, 1998
- Long-term azithromycin may improve lung function in children with cystic fibrosisThe Lancet, 1998
- Antibiotic Susceptibility of Multiply Resistant Pseudomonas aeruginosa Isolatedfrom Patients with Cystic Fibrosis, Including Candidates for TransplantationClinical Infectious Diseases, 1996
- Management of Pulmonary Disease in Patients with Cystic FibrosisNew England Journal of Medicine, 1996
- Effect on Pseudomonas aeruginosa alginate expression of direct plating and culture of fresh cystic fibrosis sputum on to pseudomonas isolation agar containing subinhibitory concentrations of roxithromycin and rifampicinJournal of Antimicrobial Chemotherapy, 1995
- In-vitro effects of antimicrobial agents on Pseudomonas aeruginosabiofilm formationJournal of Antimicrobial Chemotherapy, 1994
- Inhibition of Pseudomonas aeruginosa virulence factors by subinhibitory concentrations of azithromycin and other macrolide antibioticsJournal of Antimicrobial Chemotherapy, 1993
- The changing epidemiology of cystic fibrosisThe Journal of Pediatrics, 1993
- Mucoid Pseudomonas aeruginosa is a marker of poor survival in cystic fibrosisPediatric Pulmonology, 1992