The Pressure‐Flow Relationship in Renal Cortical and Medullary Circulation

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Abstract
The perfusion pressure‐red cell flow relationship in the cortical and in the outer and inner medullary circulation has been investigated on 9 chloralos anesthetized mongrel dogs using an indicator‐dilution technique with 32‐P labelled red cells and internal detection with small needle‐shaped semiconductor detectors. The perfusion pressure was varied by a clamp on the aorta. High pressures were obtained by ligation of the carotid arteries and section of the vagal nerves preceded by denervation of the renal nerves. The change in red cell flow on changing the perfusion pressure was determined from 1. the change in the regional mean transit time and 2. the change in regional red cell volume. The flow in all the regions studied was then found to be lineary related to the perfusion pressure up to some 70 mm Hg, whereas in the pressure range between 70 and 200 mm Hg it remained essentially unchanged. The findings indicate an autoregulative response in both the cortical and medullary circulation.

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