Key Note Lecture Review article Vulvovaginitis due toCandida glabrata.An emerging problem
- 1 October 1998
- Vol. 41, 18-22
- https://doi.org/10.1111/j.1439-0507.1998.tb00594.x
Abstract
Summary. A review is presented of the emerging problem of resistant and chronic vaginitis due to Candida glabrata. Although accurate numbers are lacking, several investigators report encountering increased numbers of women with vaginitis due to C. glabrata. Possible reasons for this apparent increase are discussed. Risk factors and clinical manifestations of symptomatic C. glabrata vaginitis differ from those of C. albicans, C. glabrata being less susceptible to fungistatic azole agents is more difficult to eradicate. Successful management of chronic C. glabrata vaginitis constitutes a major challenge with currently available therapeutic agents. Zusammenfassung. Es wird eine Übersicht gegeben über die zunehmende Problematik therapieresistenter und chronischer Vaginitis verursacht durch Candida glabrata. Obwohl genaue Zahlen fehlen, berichten mehrere Untersucher über steigende Zahlen von Frauen mit C. glabrata‐Vaginitis. Die möglichen Gründe für diese offensichtliche Zunahme werden diskutiert. Risikofaktoren und klinisches Bild der symptomatischen C. glabrata‐Vaginitis unterscheiden sich von denen der Candida albicans. C. glabrata ist weniger empfindlich für fungistatische Azol‐Präparate und ist schwieriger zu beseitigen. Die erfolgreiche Behandlung der chronischen C. glabrata‐Vaginitis stellt mit den derzeit verfügbaren therapeutischen Mitteln eine zunehmende Herausforderung dar.Keywords
This publication has 11 references indexed in Scilit:
- Torulopsis glabrata VaginitisPublished by Wolters Kluwer Health ,2000
- Mucosal Candidal Colonization and Candidiasis in Women with or at Risk for Human Immunodeficiency Virus InfectionClinical Infectious Diseases, 1998
- Vulvovaginal candidiasis: Epidemiologic, diagnostic, and therapeutic considerationsAmerican Journal of Obstetrics and Gynecology, 1998
- Weekly Fluconazole for the Prevention of Mucosal Candidiasis in Women with HIV InfectionAnnals of Internal Medicine, 1997
- Treatment of Torulopsis glabrata Vaginitis: Retrospective Review of Boric Acid TherapyClinical Infectious Diseases, 1997
- A Murine Model of Candida glabrata VaginitisThe Journal of Infectious Diseases, 1996
- Role of antifungal drug resistance in the pathogenesis of recurrent vulvovaginal candidiasisMedical Mycology, 1996
- Comparativein vitroactivity of antimycotic agents against pathogenic vaginal yeast isolatesMedical Mycology, 1994
- Development of resistance in candida isolates from patients receiving prolonged antifungal therapyAntimicrobial Agents and Chemotherapy, 1991
- Relative effectiveness of various yeasts, Candida spp. and Torulopsis glabrata, for inducing palatal infection in the Wistar ratArchives of Oral Biology, 1983