Forensic Toxicology of Some Deaths Associated with the Combined Use of Propoxyphene and Acetaminophen (Paracetamol)

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Abstract
For many years the most commonly encountered mild analgesic in cases of poisoning in the United Kingdom and particularly in London was aspirin. Often aspirin was formulated with phenacetin and codeine and sometimes with caffeine. Chronic use of phenacetin was found to cause renal damage, but, though acetaminophen is a metabolite of phenacetin, there is no evidence that it does harm to the kidney. Acetaminophen is itself a mild analgesic that has gained favor as an alternative to both phenacetin and aspirin since it does not cause gastric ulceration and hemorrhage when taken orally.