Primate antibodies to components of the human immune system
- 1 July 1994
- journal article
- Published by Wiley in Journal of Medical Primatology
- Vol. 23 (5) , 285-297
- https://doi.org/10.1111/j.1600-0684.1994.tb00286.x
Abstract
The feasibility to raise nonhuman primate antibodies against selected components of the human immune system was tested. The immunogens were whole cells (human T lymphocytes) or purified, recombinant human proteins (cytokines: TNFα or GM-CSF; soluble forms of cell surface antigens: sCD4 or sCD25). Significant immunizations, yielding functionally relevant antibodies, were readily achieved in rhesus monkeys, but, not surprisingly, may be less frequent in chimpanzees. The results suggest a general strategy for production of therapeutically useful MAB.Keywords
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