INTERACTION OF GENISTEIN WITH OESTRADIOL IN THE REPRODUCTIVE TRACT OF THE OVARIECTOMIZED MOUSE

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Abstract
It is not clear whether genistein and certain related isoflavones are 'pro-oestrogens' (i.e. whether they are metabolized to highly active oestrogenic compounds) as proposed by Biggers & Curnow (1954), or whether they are weak oestrogens which can interact with potent oestrogens as suggested by Folman & Pope (1966). Jensen & Jacobson (1962) and Stone (1964) have shown that in rodents the uterus and vagina are able to incorporate and retain certain very active oestrogenic compounds. This fact was utilized in an attempt to demonstrate the presence of highly active oestrogenic metabolites of genistein in the reproductive tract of ovariectomized mice after the administration of genistein. Oestrogenic activity in extracts of the uterus and vagina from the mice were assayed by the intravaginal (i.vg.) tetrazolium method of Martin (1964). Extracts were obtained from groups of ovariectomized mice (7–12 weeks old, 18–25 g.) of the Sydney White strain. Substances were administered as

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