Elevated soluble intercellular adhesion molecules-1 in inflammatory myopathy
- 29 January 1997
- journal article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 95 (1) , 34-37
- https://doi.org/10.1111/j.1600-0404.1997.tb00065.x
Abstract
Introduction – We evaluated the serum level of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with polymyositis (PM) and dermatomyositis (DM) and investigated the correlation between the serum level of sICAM-1 and clinical findings. Material and methods – We measured the serum level of sICAM-1 using an enzyme-linked immunosorbent assay in 19 untreated patients with inflammatory myopathy (14 patients with PM and 5 patients with DM), 20 patients with other neuromuscular disorders in which immunological mechanisms are unlikely to be involved, and 14 normal healthy controls. Results – The serum level of sICAM-1 was significantly higher in patients with PM/DM compared with patients with other neurological disorders and control subjects. The sICAM-1 level was, however, not correlated with the clinical characteristic including disease severity, the duration of illness, and the serum level of CK. Conclusion – These findings suggest that sICAM-1 is involved in the inflammatory process of PM and DM.Keywords
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