(5R)-7,8:9,10-Di-O-isopropylidene-2,6-dioxa-4-azaspiro[4,5]decan-3-one: a new chiral spirooxazolidin-2-one derived from D-(+)-galactose for use in asymmetric transformations
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 14,p. 1146-1148
- https://doi.org/10.1039/c39930001146
Abstract
Starting from D-(+)-galactose, the crystalline spirooxazolidin-2-one 2 can be readily prepared in an optically pure state by a nitrene-mediated four-step sequence, and serves to control both aldol and Diels–Alder reactions with high chiral efficiency, being easy to remove after use.Keywords
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