The NOTCH4 locus is associated with susceptibility to schizophrenia
- 1 August 2000
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 25 (4) , 376-377
- https://doi.org/10.1038/78044
Abstract
Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A→G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.Keywords
This publication has 7 references indexed in Scilit:
- Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutationsProceedings of the National Academy of Sciences, 1999
- Cloning, Characterization, and the Complete 56.8-Kilobase DNA Sequence of the Human NOTCH4 GeneGenomics, 1998
- Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch geneDevelopment, 1996
- Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib–pair linkage analysisNature Genetics, 1995
- A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneityNature Genetics, 1995
- Evidence for a susceptibility locus for schizophrenia on chromosome 6pter–p22Nature Genetics, 1995
- Notch: Neurogenesis is only part of the pictureCell, 1993