Hemodynamic responses to controlled 100% oxygen breathing in emphysema

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Abstract
Cardiopulmonary hemodynamic responses to breathing 100% oxygen for 20 min were studied in 13 patients with moderate to severe chronic obstructive emphysema under conditions of controlled ventilation. A technique for regulating the level of ventilation in the unanesthetized subject is described. Cardiac output was measured by the indicator-dilution method. Arterial blood gas analysis and pH were performed in each phase of the study. A slight but statistically significant decrease in cardiac index occurred. There was a highly significant reduction in pulmonary arterial pressure and pulmonary vascular resistance. No change in heart rate, pulmonary wedge pressure, or aortic pressure occurred. It is concluded that oxygen breathing caused a release, in part at least, of a pulmonary vasoconstrictive element in these patients. pulmonary circulation; oxygen in pulmonary hypertension; hypoxia and pulmonary vasoconstriction; controlled ventilation during oxygen inhalation Submitted on May 27, 1964