Pharmacokinetic Properties of Phosphorothioate Oligonucleotides
- 1 July 1997
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 16 (7-9) , 1689-1693
- https://doi.org/10.1080/07328319708006256
Abstract
The pharmacokinetic parameters determined for different phosphorothioate oligonucleotides were compared. The data suggest that phosphorothioate pharmacokinetics are primarily determined by chemical class. The pharmacokinetics are consistent across species, show dose-dependency, and are independent of sequence.Keywords
This publication has 1 reference indexed in Scilit:
- Quantitation of Phosphorothioate Oligonucleotides in Human PlasmaAnalytical Biochemistry, 1996