Hepatitis B surface antigen and polymerized albumin binding activity in sheep serum.

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Abstract
Sera from sheep and other domestic animals contain a substance that gives a strongly positive test for antibody to hepatitis B virus surface antigen, as found by the accepted radioimmunoassay procedure. This substance was purified from sheep serum to near homogeneity by ion-exchange, affinity and molecular exclusion chromatography, and it was identified as an IgM. This sheep IgM is an antibody to polymerized sheep albumin. This antibody may arise due to infection by hepatitis B virus, hepatitis B virus-like viruses or other pathological agents, and may react with hepatitis B virus surface antigen by combining with polymerized albumin bound to the hepatitis B virus receptor for this polymer.