Studies on Diabetic Cataract in Rats Induced by Streptozotocin

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Abstract
Biochemical examinations of streptozotocin-induced diabetic cataracts in rats were performed and related to different stages of lens opacifications. Sorbitol levels in lenses showed maximum accumulation at stages I–III and began to decrease from stage IV. Glucose levels indicated a relatively constant accumulation, but became higher between stage V and VI. Fructose levels increased less significantly from stage I-IV, and slightly decreased thereafter. Inositol was not detectable from stage I. The sodium-potassium ratio (Na/K) increased slowly from stage I-IV, and rose remarkably at stage V. Hydration of the lenses showed no change between stage I and IV, and after stage V it rose markedly.