The HL‐A7 Histocompatibility Antigen in Sarcoidosis Relation to Tuberculin Sensivity

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Abstract
Eighty cases of sarcoidosis have been investigated. In all except eight patients a histological verification of the diagnosis was obtained by mediastinoscopy or liver biopsy. The HL‐A7 antigen was not increased in the entire group. However, in the group of patients with a negative sensitivity to tuberculin after the appearance of the disease there was a significant increase compared with controls. In the patients with a positive reaction, there was a complete absence of HL‐A7. The HL‐A system therefore does not seem to influence the liability to contract sarcoidosis, but once this condition has developed HL‐A7 positives are more likely to lose cellular immunity to tuberculin and to reveal symptoms.

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