Localization of cloned mouse chromosome 7-specific DNA to lethal albino deletions
- 1 May 1984
- journal article
- research article
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 10 (3) , 211-215
- https://doi.org/10.1007/bf01535243
Abstract
Mouse chromosome X- and 7-specific DNA fragments have been isolated from a recombinant DNA library enriched for X(7) chromosome sequences. The library was enriched by flow sorting the X(7) chromosome, a derivation of the Cattanach translocation, prior to library construction. A DNA fragment was found to be located in a region deleted in newborn mice doubly heterozygous for the two albino deletions c3H and c6H in chromosome 7. These chromosome-specific DNA fragments will be useful for studying X inactivation spreading in the X-autosome translocation (T(X;7)1Ct) and for investigating the developmental effects of the lethal albino deletions.Keywords
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