Syntheses of N-alkyl-N-(.OMEGA.-carboxyalkyl)nitrosamines related to N-butyl-N-(3-carboxypropyl)nitrosamine, principal urinary metabolite of a potent bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine.
- 1 January 1978
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 26 (12) , 3909-3913
- https://doi.org/10.1248/cpb.26.3909
Abstract
N-alkyl-N-(.omega.-carboxyalkyl)nitrosamines (14) related to N-butyl-N-(3-carboxypropyl)nitrosamine, principal urinary metabolite of a potent bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine, were prepared to characterize urinary metabolites and test their carcinogenic effects in rats. They were N-alkyl-N-(3-carboxypropyl)nitrosamines, N-alkyl-N-(2-carboxyethyl)nitrosamines, and N-alkyl-N-(carboxymethyl)nitrosamines. They were mostly prepared by the permanganate oxidation of the corresponding N-alkyl-N-(.omega.-hydroxyalkyl)nitrosamines.This publication has 4 references indexed in Scilit:
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- Selective Catalytic Oxidation of Carbohydrates, Employing Platinum CatalystsPublished by Elsevier ,1963