Acyclic Nucleosides other than Acyclovir as Potential Antiviral Agents
- 1 July 1985
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 4 (3) , 411-427
- https://doi.org/10.1080/07328318508056172
Abstract
In the past few years interest in the synthesis and biological properties of acyclic nucleosides has been generated based largely upon the development of acyclovir [9-[(2-hydroxyethoxy)methyll guanine, 1a] as an antiviral agent for the treatment of certain herpesvirus infections. The literature in the area covers a variety of different heterocycles, a variety of different side chains, and spans research that is strictly synthetic to research that is strictly biological. Two compounds, 9-[(2-hydroxy-l-(hydroxymethyl)ethoxy)methyl] guanine (1b) and 9-(S)-(2,3-dihydroxypropyl)adenine (2), have received the most attention, but many others have been made.Keywords
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