Trichothecene Biosynthesis in Fusarium sporotrichioides : Origin of the Oxygen Atoms of T-2 Toxin
- 1 March 1986
- journal article
- research article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 51 (3) , 493-497
- https://doi.org/10.1128/aem.51.3.493-497.1986
Abstract
Mass spectral analysis of T-2 toxin formed during the growth of Fusarium sporotrichioides (ATCC 24043) in the presence of H 2 18 O showed incorporation of up to three 18 O atoms per toxin molecule. The carbonyl oxygens of the acetates at C-4 and C-15 and of the isovalerate at C-8 were derived from H 2 O. Toxin formed in the presence of 18 O molecular oxygen incorporated up to six 18 O atoms per toxin molecule. The overall incorporation was 78 and 92% of toxin molecules labeled for H 2 18 O and 18 O 2 labeled samples, respectively. The oxygens of position 1, the 12,13-epoxide, and the hydroxyl groups at C-3, C-4, C-8, and C-15 were all derived from molecular oxygen.This publication has 1 reference indexed in Scilit:
- Tandem Mass SpectrometryScience, 1981