Suppression of antibodies to nucleic acids with polyinosinic-polycytidylic acid and cyclophosphamide in murine lupus.

  • 1 November 1970
    • journal article
    • Vol. 7  (5) , 687-91
Abstract
NZB/NZW mice with active lupus were treated with polyinosinic·polycytidylic acid, a synthetic double stranded RNA, followed by cyclophosphamide to induce immunologic tolerance to nucleic acids. This combined regimen reduced serum antibodies to RNA and DNA to a greater degree than did cyclophosphamide alone. This report demonstrates that a specific form of immunotherapy can be successfully employed to treat the serologic abnormalities of murine lupus.