Lipid mobilization in obese hypophysectomized cockerels

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Abstract
Levels of free fatty acids (FFA) and glucose in the plasma of obese hypophysectomized cockerels have been measured following treatments which cause lipid mobilization. Hypophysectomized cockerels had normal resting concentrations of glucose and FFA in the plasma. During fasting for as little as 9 hr. they became slightly hypoglycemic, but they maintained this level without severe hypoglycemia for at least 96 hr. Fasting for 24 hr. caused lipid mobilization in intact and hypophysectomized birds as shown by increases in plasma FFA levels, but the response was earlier and more consistent in the intact birds. Nonspecific stress caused by injection of propylene glycol raised FFA levels in intact birds but not in hypophysectomized birds. Avian pituitary powder contained substances which raised FFA levels, but testosterone did not cause immediate mobilization. It was suggested that impaired fat mobilization may play a part in the development of obesity in hypophysectomized cockerels.

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