Discovery and optimization of nonpeptide HIV-1 protease inhibitors

This publication has 32 references indexed in Scilit:

• On the size of the active site in proteases. I. Papain
  Published by Elsevier ,2005
• In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
  Nature, 1995
• Competitive Inhibition of HIV-1 Protease by Warfarin Derivatives
  Biochemical and Biophysical Research Communications, 1994
• Competitive Inhibition of HIV-1 Protease by 4-Hydroxy-benzopyran-2-ones and by 4-Hydroxy-6-phenylpyran-2-ones
  Biochemical and Biophysical Research Communications, 1994
• Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors
  Science, 1994
• STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE
  Annual Review of Biochemistry, 1993
• Using three-dimensional substructure searching to identify novel, non-peptidic inhibitors of HIV-1 protease
  Tetrahedron Computer Methodology, 1990
• Design, Activity, and 2.8 Å Crystal Structure of a C ₂ Symmetric Inhibitor Complexed to HIV-1 Protease
  Science, 1990
• Sub‐site preferences of the aspartic proteinase from the human immunodeficiency virus, HIV‐1
  FEBS Letters, 1990
• HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins
  Biochemical and Biophysical Research Communications, 1988