Investigations into the Mechanism of the Liberation of Renin in Ischemic Kidneys.

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Abstract
Summary.: The mechanism for the liberation of renin in totally ischemic kidneys was ascertained in investigations showing that, by perfusing the kidneys with various capillary‐injuring substances such as toluol, phenol, acetone, hypertonous salt solution and saponin, one obtains a liberation of renin which is best explained as a diffusion through injured capillaries and cell membranes, the permeability of which has been increased. This view is also borne out by examining the content in the perfusates of another renal enzyme, namely phosphatase. There is in fact a rather close relation between the content of renin and phosphatase. We must reckon with the possibility that the same mechanism is found in the abnormal liberation of renin in renally induced hypertension in man and animals.