Penetration of Methicillin, Oxacillin, and Cephalothin into Bone and Synovial Tissues
Open Access
- 1 November 1978
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 14 (5) , 723-726
- https://doi.org/10.1128/aac.14.5.723
Abstract
The penetrations of methicillin, oxacillin, and cephalothin into cortical bone and synovial tissues were studied 1 h after their intravenous administration in 105 patients having arthroplasty of the hip. Although the lowest serum levels were noted with cephalothin ( P < 0.01), more patients receiving cephalothin achieved osseous drug levels inhibitory to staphylococci ( P < 0.01). Differences in the penetration of the three agents into synovial tissues were not statistically significant.Keywords
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