Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications
- 4 November 2008
- journal article
- review article
- Published by Springer Nature in Amino Acids
- Vol. 36 (4) , 659-670
- https://doi.org/10.1007/s00726-008-0190-y
Abstract
This review summarises the functions of the enzyme tissue transglutaminase (TG2) in the extracellular matrix (ECM) both as a matrix stabiliser through its protein cross-linking activity and as an important cell adhesion protein involved in cell survival. The contribution of extracellular TG2 to the pathology of important diseases such as cancer and fibrosis are discussed with a view to the potential importance of TG2 as a therapeutic target. The medical applications of TG2 are further expanded by detailing the use of transglutaminase cross-linking in the development of novel biocompatible biomaterials for use in soft and hard tissue repair.Keywords
This publication has 110 references indexed in Scilit:
- Tissue Transglutaminase Contributes to Interstitial Renal Fibrosis by Favoring Accumulation of Fibrillar Collagen through TGF-β Activation and Cell InfiltrationThe American Journal of Pathology, 2008
- Novel interactions of TG2 with heparan sulfate proteoglycans: reflection on physiological implicationsAmino Acids, 2008
- Fibronectin-Tissue Transglutaminase Matrix Rescues RGD-impaired Cell Adhesion through Syndecan-4 and β1 Integrin Co-signalingJournal of Biological Chemistry, 2008
- Tissue Transglutaminase Expression and Activity in Normal and Glaucomatous Human Trabecular Meshwork Cells and TissuesInvestigative Opthalmology & Visual Science, 2008
- Facile coupling of synthetic peptides and peptide–polymer conjugates to cartilage via transglutaminase enzymeBiomaterials, 2007
- Transglutaminase 2 Undergoes a Large Conformational Change upon ActivationPLoS Biology, 2007
- Tissue transglutaminase in tumour progression: friend or foe?Amino Acids, 2007
- Transglutaminase-mediated gelatin matrices incorporating cell adhesion factors as a biomaterial for tissue engineeringJournal of Bioscience and Bioengineering, 2003
- The Hallmarks of CancerCell, 2000
- Site-directed mutagenesis of human tissue transglutaminase: Cys-277 is essential for transglutaminase activity but not for GTPase activityBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993