Experimental Epilepsy in the Mouse.

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Abstract
Implantation in mouse brain of various powdered metals, notably Co and Ni, induced a chronic convulsive state with certain features previously noted in experimental monkey epilepsy. In addition to spontaneous focal and generalized seizures, Co treated mice when challenged with Metrazol (pentetrazole, 30 mg/kg subcutaneously) showed a lowered seizure threshold by the second week (40%), with peak incidence of reactivity by the fourth week (92.3%), and a relatively constant convulsive level from the third to tenth month (37.3-40%). Semicarbazide challenge (50 mg/kg intraperitoneally) at 5-10 months proved more effective (64.4%) than Metrazol. Control mice, untreated or with cerebral talc or Falba implantation, failed to exhibit spontaneous seizures and remained negative to challenge with the convulsant drugs. In addition, electroshock technics for inducing psychomotor and submaximal seizures indicated a significantly lower threshold among the experimental group.