A Facile Synthesis of Polyfunctionally Substituted Pyridines from Ethoxycarbonylmalonaldehyde
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (05) , 400-402
- https://doi.org/10.1055/s-1986-31651
Abstract
A facile access to 2,3-disubstituted-5-ethoxycarbonylpyridines (50-66% yields), derivatives of biologically and medicinally important nicotinic acid, is explored. The method involves the reaction of ethoxycarbonylmalonaldehyde with tosyl chloride and then with β-amino-α,β-unsaturated esters, ketones, or nitriles in the presence of pyridine.Keywords
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