Lethal Action of Quinolones against a Temperature-Sensitive dnaB Replication Mutant of Escherichia coli
Open Access
- 1 January 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (1) , 362-364
- https://doi.org/10.1128/aac.50.1.362-364.2006
Abstract
Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.Keywords
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