Cigarette Smoking and Duodenal-Ulcer Disease

Abstract
Smoking has been associated with many pathologic processes in and outside the respiratory system; but whether smoking causes a disease, whether smoking and the disease result from common causes, or whether smoking and the disease are present together in the same person by chance are undetermined alternatives for most of the associations observed. What is usually lacking is a defined pathophysiologic mechanism that links the habit and the disorder. A case in point is the relation of tobacco smoking to duodenal-ulcer disease. Recently, we have defined a mechanism that connects a common disease and a very common habit by something . . .