A note on a series of decamethylenebis[(4-substituted amino)quinaldinium] salts with potent antibacterial properties

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Abstract
A number of decamethylenebis[4-(substituted amino)quinaldinium acetates] have been prepared and certain of these showed markedly increased antibacterial activity compared with the unsubstituted compound. Local therapeutic activity, assessed by mouse protection tests, reached a maximum in the C3–C6 range of the n-alkylamino-homologues, but increased activity was associated with increased toxicity.