TRIMETHOPRIM AND SULFADIAZINE - EXPERIMENTAL-INFECTION OF BEAGLES

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (7) , 1117-1122
Abstract
The purpose in the present study was to determine whether the commercial combination of trimethoprim (TMP) and sulfadiazine (SDZ) tribissen (TRI) was more effective than was either of the components for treating experimentally-induced infection of Streptococcus zooepidemicus. Two dose levels of each were given s.c. for treatment, and their effectiveness was compared with that of sulfadimethoxine (SDM) in terms of clinical manifestations, hematologic changes, blood culture examinations and tissue culture examinations. According to these 4 measurements, the combination TMP/SDZ was more effective than either of the components. This effect was observed at the 2 dosages of TRI (30 and 15 mg/kg). The higher dosage was more effective as demonstrated by 3 of the measurements. Alone, TMP and SDZ were not effective, but SDM treatment was effective in this model.

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