STUDY ON THE KINETICS OF GLOBULE LEUKOCYTES IN THE INTESTINAL EPITHELIUM OF RATS AFTER SINGLE OR DOUBLE INFECTION WITH TRICHINELLA-SPIRALIS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 61  (3) , 285-290
Abstract
The interdependence of IMC [intestinal mast cells] and GL [intestinal globule leukocytes] in the rat and the kinetics of GL in the intestinal epithelium were examined. For this purpose rats received a single or double infection with the nematode T. spiralis. After the double infection worms were rapidly expelled. The numbers of IMC and GL were related to the degree of infection. IMC were always observed evenly distributed through the stroma of the villus. During infection, GL were shown to shift from a predominantly infranuclear position in the crypt of Lieberkuehn and the base of the villus, to a supranuclear position in the base and mid-villus region. This was evidence for active migration of GL through the epithelial lining. The fact that GL were 1st observed in the crypt and basal villus region and the consecutive kinetics could be interpreted as evidence for the independence of GL from IMC. A preferential migration of degranulated IMC to the crypt and basal villus region cannot be excluded.