SYSTEMIC AND RENAL CIRCULATORY CHANGES FOLLOWING THE ADMINISTRATION OF ADRENIN, EPHEDRINE, AND PAREDRINOL TO NORMAL MAN

Open Access
Publisher Website
Google Scholar
Abstract
A study of the systemic and renal circulatory effects of adrenin, ephedrine, and paredrinol was made in 31 normal subjects. Cardiac output was measured with the ballistocardiograph, arterial pressure with the Hamilton manometer, and right intra-auricular pressure, following catheterization of the right heart, with a saline manometer. Effective renal plasma flow was detd. as the diodrast clearance, glomerular filtration rate as the mannitol or inulin clearance, and the mannitol/diodrast ratio as the filtration fraction. Adrenin and ephedrine behaved similarly. Evidence was adduced to support the view that the vasodilator action of these substances dominated the hemo-dynamic picture with an increase in the cardiac output, associated with increased intra-auricular pressure, producing the pressor effects. Increased pulse pressure, without corresponding increases in stroke vol. or cardiac output, indicated a direct action upon the central arteries. Paredrinol caused an increase in the peripheral resistance and arterial pressure with a fall in cardiac output in the face of increased right auricular pressure. It was inferred that paredrinol increased cardiac tone. All these substances reduced renal blood flow and increased the filtration fraction, indiacting efferent arteriolar vasoconstriction.