Verapamil and Lithium in Maintenance Therapy of Manic Patients

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Abstract
A year‐long double‐blind cross‐over study was used to compare the long‐term therapeutic effects of lithium versus verapamil in a group of 20 manic volunteers. Subjects received each medication for six months. Before cross‐over, verapamil patients showed a significant improvement after 60 days, lithium‐treated patients after 180 days. After cross‐over, verapamil‐treated subjects showed improvement at day 240. Lithium‐treated patients showed no improvement after cross‐over. The data indicate that verapamil may be effective as an agent in the maintenance treatment of manic patients.