Day‐Night Rhythm of Rat Pineal Tyrosine Hydroxylase Activity as Determined by HPLC with Amperometric Detection
- 1 March 1987
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 48 (3) , 665-668
- https://doi.org/10.1111/j.1471-4159.1987.tb05566.x
Abstract
Tyrosine hydroxylase activity in the rat pineal gland was measured by means of HPLC determination of the amount of l‐3,4‐dihydroxyphenylalanine formed. Enzyme activity showed a clear day‐night rhythm, paralleling that of plasma melatonin levels in the same animals, with values being high during the dark period apparently because of changes in Vmax. In animals maintained under constant illumination for 3 days, tyrosine hydroxylase activity and plasma melatonin level rhythms were completely abolished, a result indicating that both are under photoperiodic control.Keywords
This publication has 20 references indexed in Scilit:
- Changes in Serotonin Levels, N-Acetyltransferase Activity, Hydroxyindole-O-Methyltransferase Activity, and Melatonin Levels in the Pineal Gland of the Richardson’s Ground Squirrel in Relation to the Light-Dark CycleNeuroendocrinology, 1984
- Tyrosine hydroxylase activation in depolarized dopaminergic terminals—involvement of Ca2+ -dependent phosphorylationNature, 1983
- Analysis of fluctuations in the activity of rat pineal tyrosine hydroxylaseNeurochemistry International, 1981
- The Activity of Rat Pineal and Brain Tyrosine Hydroxylase During the Daily Cycle of Light and Darkness as Determined by the Modified 14CO2 Assay MethodJournal of Neurochemistry, 1981
- Preganglionic nerve stimulation increases the amount of tyrosine hydroxylase in the rat superior cervical ganglionNeuroscience Letters, 1980
- Diurnal rhythm in rat pineal cyclic nucleotide phosphodiesterase activityNature, 1976
- Pineal Gland: 24-Hour Rhythm in Norepinephrine TurnoverScience, 1974
- A retinohypothalamic projection in the ratJournal of Comparative Neurology, 1972
- Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N -AcetyltransferaseScience, 1970
- A 24-hour rhythm in the content of norepinephrine in the pineal and salivary glands of the ratLife Sciences, 1966