Hydroxylation of 10-Deoxoartemisinin byCunninghamella elegans
- 30 July 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 67 (9) , 1595-1597
- https://doi.org/10.1021/np040089c
Abstract
The microbial metabolism of 10-deoxoartemisinin (1), a derivative of the antimalarial drug artemisinin, was investigated. Various strains of fungi were investigated for their ability to transform 1. Of these microorganisms, only Cunninghamella elegans was capable of transforming 1 to 5β-hydroxy-10-deoxoartemisinin (2), 4α-hydroxy-1,10-deoxoartemisinin (3), and 7β-hydroxy-10-deoxoartemisinin (4). The metabolites 2 and 4 retained an intact peroxide group and are therefore useful scaffolds for synthetic modification in the search for new antimalarial agents.Keywords
This publication has 9 references indexed in Scilit:
- Microbial Metabolism of Artemisinin by Mucor polymorphosporus and Aspergillus nigerJournal of Natural Products, 2002
- Microbial transformations of artemisinin by Cunninghamella echinulata and Aspergillus nigerTetrahedron Letters, 2002
- Biotransformation of 10-deoxoartemisinin to its 7β-hydroxy derivative by Mucor ramannianusBiotechnology Letters, 2002
- Regioselective transformation of ciprofloxacin toN-acetylciprofloxacin by the fungusMucor ramannianusFEMS Microbiology Letters, 1999
- Microbial metabolism of artemisitenePhytochemistry, 1999
- Microbial Transformation of ArtemetherJournal of Natural Products, 1996
- 1α-Hydroxyarteether, a New Microbial Transformation ProductJournal of Natural Products, 1995
- Microbial and Mammalian Metabolism Studies on the Semisynthetic Antimalarial, DeoxoartemisininPharmaceutical Research, 1995
- Current Developments in the Chemistry of Artemisinin and Related CompoundsCurrent Medicinal Chemistry, 1994