Ethylenediamine as a Specific Releasing Agent of γ‐Aminobutyric Acid in Rat Striatal Slices

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Abstract
Following incubation with [14C]y‐aminobutyric acid (GABA) or [3H]dopamine, slices of rat striatum were superfused with media containing 36 mM K+ or ethylenediamine (EDA), 1 or 5 mM. Both K+ and EDA induced a release of [14C]GABA, the K+‐induced release being largely Ca2+‐dependent, while the EDA‐induced release was not. Whereas K+ also evoked a Ca2+‐dependent release of [3H]dopamine, EDA evoked no release of dopamine. EDA may therefore have potential as a specific GABA releasing agent.