Prevention of Insulin Aggregation by Dicarboxylic Amino Acids During Prolonged Infusion
- 1 January 1981
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 30 (1) , 83-85
- https://doi.org/10.2337/diab.30.1.83
Abstract
The dicarboxylic amino acids, aspartic acid and glutamic acid, at their isoelectric pH, reduced aggregation of insulin solutions in vitro for 16 days during continuous agitation at 37°C. Unprotected insulin solutions, when infused via a 14-day impiantatile infusion device in diabetic Chinese hamsters, controlled plasma glucose levels for only 2 days, followed by escape coincident with insulin aggregation. However, when insulin solutions were protected with glutamic acid, euglycemia was maintained for the 14-day life of the device.Keywords
This publication has 0 references indexed in Scilit: