Purposeful Change of Staphylococcal Bacteriophage Types

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Abstract
SHINEFIELD and his co-workers have demonstrated the feasibility of inoculating newborn infants as well as adults with a special strain of Staphylococcus aureus (strain 502A) to prevent colonization by more virulent strains.1,2 Strain 502A was selected because it had never been observed to produce disease. This report describes an attempt to prevent recurrences of staphylococcal abscesses in a patient by replacing a resident Staphylococcus aureus (bacteriophage type 52/52A/80) with Shinefield's strain 502A (bacteriophage type 7/47/53/54/77). Report of a Case The patient, a 43-year-old housewife, was admitted to the University of California hospital on Dec 10, 1963, with a history of recurrent furuncles and carbuncles which began at the age of 35, shortly after hospitalization for accident-induced trauma. The lesions occurred approximately every two months on any part of the skin, sparing only the palms and the soles. They were 2 to 8 cm in diameter, exceedingly painful when fully

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