INTERFERENCE OF DICHLOROMETHANE DIPHOSPHONATE WITH PARATHYROID-HORMONE EFFECTS AT THE BONE BUT NOT AT THE KIDNEY LEVEL

  • 1 January 1982
    • journal article
    • research article
    • Vol. 7  (3) , 122-126
Abstract
Treatment with dichloromethane diphosphonate [which inhibits osteoclastic bone resorption] (Cl2MDP, 10 mgP/kg s.c. for 3 days) did not abolish the rapid hypocalciuric effect of acute administration of parathyroid hormone (PTH) to thyroparathyroidectomized (TPTX) rats. Cl2MDP impaired the slower hypercalcemic response to PTH. This latter effect of Cl2MDP evidently did not result from increased renal excretion of Ca. Cl2MDP did not interfere with the kidney but with the bone effect of PTH. This finding explains the fact that under treatment with Cl2MDP, there is still an effective regulation of plasma Ca.

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