The metabolic fate of 4-amino-2-(4-butanoyl-hexahydro-1H-1, 4-diazepin-1-y1)-6, 7-dimethoxy-quinazoline HCI
- 1 January 1982
- journal article
- Published by Taylor & Francis in Xenobiotica
- Vol. 12 (9) , 549-559
- https://doi.org/10.3109/00498258209038934
Abstract
1. 4-Amino-2-(4-butanoyl hexahydro-1H-1, 4-diazepin-1-yl)-6, 7-dimethoxy [2-14C]quinazoline HCl (14C-DDQ) is rapidly absorbed in rats and rabbits and excreted mainly into faeces via the bile. 2. The main metabolites in tissues and excreta are O- and N-glucuronides of 7-O-desmethyl DDQ in rats and the N-glucuronide of DDQ in rabbits. 3. Significant enterohepatic circulation of the metabolites occurs in rats. 4. The absorption of DDQ is also rapid in healthy humans and the plasma concentration decreases with an apparent half-life of 1 . 53h.Keywords
This publication has 5 references indexed in Scilit:
- Comparison of pre- and postsynaptic .ALPHA.-adrenoceptor blocking effects of E-643 in the isolated vas deferens of the rat.The Japanese Journal of Pharmacology, 1981
- Effects of alpha blockers on blood pressure and on the Ca-contracture of cat aortic strips.The Japanese Journal of Pharmacology, 1980
- PrazosinDrugs, 1977
- Synthesis and identification of the major metabolites of prazosin formed in dog and ratJournal of Medicinal Chemistry, 1977
- The Metabolic Fate of PrazosinXenobiotica, 1977